| Demalearbak | Дата: Суббота, 02.03.2013, 23:34 | Сообщение # 1 |
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Grapefruit and grapefruit juice have the potential to interact with numerous drugs. a number of organic compounds, identified as furanocoumarin derivatives, interfere with the hepatic and intestinal enzyme cytochrome p450 isoform cyp3a4 and are therefore primarily responsible for the interaction. however, bioactive compounds in grapefruit juice may also interfere with p-glycoprotein and organic anion transporting polypeptides (oatps) either increasing or decreasing bioavailability of a number of drugs. pomelo (the asian fruit which was crossed with an orange to produce grapefruit) also contains high amounts of furanocoumarin derivatives
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The following drugs are known to have potentially serious interactions with grapefruit products
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Statins, which are taken to help lower cholesterol, are one such drug. these drugs in high levels can lead to rhabdomyolysis, a condition which affects muscles and kidneys.
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