| antarlola | Дата: Воскресенье, 10.02.2013, 05:20 | Сообщение # 1 |
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Everything in the brain is a balance, though. what i mean by that is that there is a "right" amount of each neurotransmitter. so, not only can too little of a given neurotransmitter, such as dopamine, cause problems, but too much can also cause problems. you can see evidence of this when those with pd are over-medicated. rather than the rigidity and slowness of movement caused by decreased dopamine, they can have writhing, uncoordinated movements (choreiform movements). excess dopamine has also been identified in many psychotic disorders. the point of this somewhat rambling paragraph is that increased dopamine is only helpful if there is a decreased supply to start with. hope that's helpful.
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Unfortunately "wearing off" is is one of the problems with prolonged or high dosage use of levodopa. with the availability of another medication now levodopa is no longer the only first choice by patients and some doctors as the initial treatment for parkinson's disease.
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While sinemet is the most effective medication and has the least short-term side effects, it is associated with high risks of long-term side effects, such as involuntary movements (dyskinesia). used on a long-term basis, levodopa may also cause restlessness, confusion, or abnormal movements. changes in the amount or timing of the dose will usually prevent these side effects, but most experts now recommend alternatives to sinemet, such as the dopamine agonists, and use sinemet only when the alternatives fail to provide sufficient relief.
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